BEST MOOD - Mood Support Supplement
BEST MOOD - Mood Support SupplementBEST MOOD - Mood Support SupplementBEST MOOD - Mood Support Supplement
$42.99$24.99

1 Bottle2 Bottles ($22.99 Each)3 Bottles ($19.99 Each)
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FEEL YOUR BEST, EVERY DAY.


BEST MOOD™ is a clinically dosed, all-natural supplement with research-backed ingredients including KSM-66® Ashwagandha. These key ingredients work to help calm your mind, help reduce stress, and promote mental clarity. 


BEST MOOD™ contains only hand-selected ingredients that are supported by science, natural, and safe. The formula is completely stimulant-free and can be taken whenever you want to feel calm, cool, and collected. 

BEST MOOD™ works to enhance the production of mood-regulating neurotransmitters, such as GABA and serotonin, thereby promoting a better sense of well-being and stopping stress in its tracks.

  • Experience A Calm & Clear Mind

  • Improve Your Mood & Focus

  • Caffeine-Free & Vegan Friendly

Mike W.

"I have been taking Best Mood for over a week and not only do I feel good, think better, and have less stress, it has also helped me to relax and be more present with my family. When you choose Primal One Best Mood you are not only getting the Best Mood but you are getting the Best price, Best stress reduction, Best ingredients, [and] Best company that helps you become the Best you." 
- Best Mood Review      

Best Mood™ User Guide

Regular Use Directions: For enhanced mental performance, consume a serving of 2 capsules 1 time per day on an empty stomach or with a light meal.


Enhanced Use Directions: For maximum mental performance, consume a serving of 2 capsules twice per day on an empty stomach or with a light meal.


*Contains Zero Caffeine*


Warning: Food supplements should not be used as a substitute for a balanced diet and healthy lifestyle. If you are pregnant, breastfeeding, taking prescription medication or under medical supervision it is advisable to consult a GP prior to taking any supplements. Discontinue use and consult a GP if adverse reactions occur. Do not exceed stated dose. 

*Do Not Exceed 4 Capsules in a 24 Hour Period

The Ingredients & Science

  • KSM-66
    Ashwagandha
    300 MG
  • Bacopa
    Monnieri
    250 mg
  • L-Theanine
    200 mg
  • Vitamin B
    Complex
  • Magnesium
    100 mg
  • Astragin
    25 mg

KSM-66® is a patented organic ashwagandha (Withania somnifera) root extract that is standardized to contain the most bioactive constituents of any ashwagandha extract on the market. 


Ashwagandha, also referred to as Indian ginseng, is one of the most powerful natural adaptogens known to man. Adaptogens are substances that modulate our response to stress (i.e. help the body cope with external and internal stressors). 


Clinical research suggests that ashwagandha can significantly reduce stress, enhance mood, boost cognitive function, support immunity, and much more. Further findings demonstrate that supplementing with ashwagandha is an effective treatment for chronic fatigue syndrome and a variety of neurodegenerative disorders.


Ashwagandha contains a potent profile of medicinal compounds, including choline, alkaloids, saponins and steroidal lactones (specifically withanolides).Withaferin-A is arguably the most beneficial withanolide in ashwagandha, as research suggests that has anti-inflammatory, antidepressant, anti-cancer, antioxidant, and immune-boosting actions in humans. 


It’s imperative to note that many “generic” ashwagandha extract supplements on the market contain a negligible amount of withanolides, rendering the product rather useless. 


Best Mood includes KSM-66® to ensure you get the most effective, potent, and heavily researched extract of ashwagandha.

References

1. Kulkarni, S. K., & Dhir, A. (2008). Withania somnifera: an Indian ginseng. Progress in neuro-psychopharmacology and biological psychiatry, 32(5), 1093-1105. 


2. Ven Murthy, M. R., K Ranjekar, P., Ramassamy, C., & Deshpande, M. (2010). Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: 1. Ashwagandha. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents), 10(3), 238-246. 


3. Chen, L. X., He, H., & Qiu, F. (2011). Natural withanolides: an overview. Natural Product Reports, 28(4), 705-740.

Bacopa monnieri, also known as water hyssop, is a perennial herb heralded as a natural “brain tonic” in Ayurvedic medicine. The leaves of bacopa contain several unique classes of constituents, including bacosides, bacosterols, and bacosine, which are demonstrated to have anxiolytic, antidepressant, anti-inflammatory, and neuroprotective properties in humans.


In Ayurveda, bacopa is commonly paired with ashwagandha for bolstering the neuroactive benefits of both herbs. 


Contemporary research demonstrates that supplementing with bacopa leaf extract can also enhance cognitive function and improve memory/learning by acting on both the serotonin and cholinergic systems, as well as promoting neuronal growth and integrity.

References

4. Russo A, Borrelli F. Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine. (2005) 


5. Bhandari P, et al. Bacosterol glycoside, a new 13,14-seco-steroid glycoside from Bacopa monnieri. Chem Pharm Bull (Tokyo). (2006) 


6. Pase MP, et al. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. (2012)

L-Theanine was initially discovered several hundred years ago after being isolated from green tea leaves. Chemically, it is an amino acid closely similar in structure to L-glutamine and L-glutamate. L-theanine readily crosses the blood-brain barrier to enact a range of nootropic effects.


The nootropic effects of L-theanine can appropriately be summarized as “relaxed alertness”. In other words, taking L-theanine promotes calmness and tranquility while keeping you mindful and attentive. This makes L-theanine a necessary adjunct to the other ingredients in Best Mood for enhancing both mood and cognitive function. 


Supplementing with L-theanine has been shown to reduce oxidative damage in neurons, and effectively block neurotoxic actions in the brain.8 Further research has shown that consuming L-theanine actively increases alpha waves in the brain, which are known for encouraging relaxation and a heightened sense of well-being.


Moreover, if you love coffee (like the rest of the world) and thrive on a daily caffeine kick, L-theanine is the best nootropic for you. Research demonstrates that consuming caffeine in conjunction with L-theanine effectively attenuates the side effects of consuming stimulants (e.g. jitters, crashing, inability to concentrate, etc.) while also boosting the nootropic qualities of L-theanine.


Since Best Mood is a stimulant-free formula, it may be combined with other stimulant-based products. We also went ahead and created a pure L-Theanine + Caffeine product to cater to people who want to take advantage of the synergistic nature of these ingredients. 

References

7. Juneja, L. R., Chu, D. C., Okubo, T., Nagato, Y., & Yokogoshi, H. (1999). L-theanine—a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10(6), 199-204.

9. Song, C. H., Jung, J. H., Oh, J. S., & Kim, K. S. (2003). Effects of theanine on the release of brain alpha wave in adult males. Korean Journal of Nutrition, 36(9), 918-923. 

10. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological psychology, 77(2), 113-122. 

B vitamins have a vast range of biochemical actions throughout the human body and play a role in nearly every cellular metabolic reaction. B vitamins are essential for energy production, carbohydrate metabolism, cellular respiration, DNA synthesis, neurotransmission, cognitive function, hormonal regulation, and just about any other physiological process you can think of.


Longitudinal data indicates that having a deficiency in B vitamins (particularly B12 and folate) can rapidly accelerate neurodegenerative processes and increase the risk of cognitive dysfunction. In fact, recent clinical research demonstrated that supplementing with a B vitamin complex (including vitamin B12 and folic acid) was efficacious for cognitive enhancement and blocking neurodegenerative processes.


Since many people skimp on their fruit and vegetable consumption, supplementing with Best Mood is a practical and smart way to maintain healthy B vitamin intake (remember though, eating a micronutrient-rich diet is always a good idea).  

References

11. Calvaresi, E., & Bryan, J. (2001). B Vitamins, Cognition, and Aging a Review. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 56(6), P327-P339.

12. Van Uffelen, J. G., Chinapaw, M. J., van Mechelen, W., & Hopman-Rock, M. (2008). Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomized controlled trial. British journal of sports medicine.

13. Eussen, S. J., de Groot, L. C., Joosten, L. W., Bloo, R. J., Clarke, R., Ueland, P. M., ... & van Staveren, W. A. (2006). Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. The American journal of clinical nutrition, 84(2), 361-370.

Magnesium is one of the most abundant essential minerals in the human body and a key cofactor for more than 300 biochemical processes. Among a myriad of properties in humans, magnesium is necessary for healthy muscular contraction, digestion, immune function, neurotransmitter synthesis, neurotransmission, and bone mineralization.14 


While magnesium is generally present in green vegetables and various beans/lentils, current literature suggests that it is the most common mineral for the population to be deficient in due to continual decreases of natural magnesium content in plant foods (likely arising from modern cultivation processes).15


Recent neuropharmacological research has shown that hypomagnesemia (magnesium deficiency) is strongly correlated with feelings of anxiety and even panic attacks.16 Preliminary evidence suggests that low magnesium status dysregulates the hypothalamic-pituitary-adrenal (HPA) axis - the primary glands responsible for producing stress hormones (i.e. catecholamines). 


Clinical researchers postulate that restoring magnesium levels to the normal range promotes healthy cortisol rhythms, thereby alleviating feelings of anxiety and enhancing mood.17 Magnesium is also necessary for your body to properly absorb and utilize both calcium and vitamin D3, both which are integral to a multitude of physiological processes and overall well-being. 


Best Mood contains one of the most bioavailable forms of magnesium - magnesium glycinate chelate. Be wary of supplements that include magnesium oxide, which has less than 3% bioavailability and is rather useless in humans.  

References

14. Maathuis, F. J. (2009). Physiological functions of mineral macronutrients. Current opinion in plant biology, 12(3), 250-258. 

15. Guo, W., Nazim, H., Liang, Z., & Yang, D. (2016). Magnesium deficiency in plants: an urgent problem. The Crop Journal, 4(2), 83-91. 

16. Sartori, S. B., Whittle, N., Hetzenauer, A., & Singewald, N. (2012). Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology, 62(1), 304-312. 

17. Bandelow, B., Wedekind, D., Pauls, J., Broocks, A., Hajak, G. ½., & Rï¿ ½, E. (2000). Salivary cortisol in panic attacks. American Journal of Psychiatry, 157(3), 454-456.

AstraGin™ is a patented, high-potency extract of Panax notoginseng and Astragalus membranaceus that significantly increases the bioavailability and absorption of other nutrients. 


We included a clinical dose of AstraGin™ along with the other ingredients in Best Mood in order to effectively maximize the synergy and potency of the formula.

KSM-66 Ashwagandha 300 MG

KSM-66® is a patented organic ashwagandha (Withania somnifera) root extract that is standardized to contain the most bioactive constituents of any ashwagandha extract on the market. 


Ashwagandha, also referred to as Indian ginseng, is one of the most powerful natural adaptogens known to man. Adaptogens are substances that modulate our response to stress (i.e. help the body cope with external and internal stressors). 


Clinical research suggests that ashwagandha can significantly reduce stress, enhance mood, boost cognitive function, support immunity, and much more. Further findings demonstrate that supplementing with ashwagandha is an effective treatment for chronic fatigue syndrome and a variety of neurodegenerative disorders.


Ashwagandha contains a potent profile of medicinal compounds, including choline, alkaloids, saponins and steroidal lactones (specifically withanolides). Withaferin-A is arguably the most beneficial withanolide in ashwagandha, as research suggests that has anti-inflammatory, antidepressant, anti-cancer, antioxidant, and immune-boosting actions in humans.


It’s imperative to note that many “generic” ashwagandha extract supplements on the market contain a negligible amount of withanolides, rendering the product rather useless.Best Mood includes KSM-66® to ensure you get the most effective, potent, and heavily researched extract of ashwagandha.

References

1. Kulkarni, S. K., & Dhir, A. (2008). Withania somnifera: an Indian ginseng. Progress in neuro-psychopharmacology and biological psychiatry, 32(5), 1093-1105. 


2. Ven Murthy, M. R., K Ranjekar, P., Ramassamy, C., & Deshpande, M. (2010). Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: 1. Ashwagandha. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents), 10(3), 238-246. 


3. Chen, L. X., He, H., & Qiu, F. (2011). Natural withanolides: an overview. Natural Product Reports, 28(4), 705-740.

Bacopa Monnieri 250 mg

Bacopa monnieri, also known as water hyssop, is a perennial herb heralded as a natural “brain tonic” in Ayurvedic medicine. The leaves of bacopa contain several unique classes of constituents, including bacosides, bacosterols, and bacosine, which are demonstrated to have anxiolytic, antidepressant, anti-inflammatory, and neuroprotective properties in humans.


In Ayurveda, bacopa is commonly paired with ashwagandha for bolstering the neuroactive benefits of both herbs.


Contemporary research demonstrates that supplementing with bacopa leaf extract can also enhance cognitive function and improve memory/learning by acting on both the serotonin and cholinergic systems, as well as promoting neuronal growth and integrity.

References

4. Russo A, Borrelli F. Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine. (2005) 


5. Bhandari P, et al. Bacosterol glycoside, a new 13,14-seco-steroid glycoside from Bacopa monnieri. Chem Pharm Bull (Tokyo). (2006) 


6. Pase MP, et al. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. (2012)

L-Theanine 200 mg

L-Theanine was initially discovered several hundred years ago after being isolated from green tea leaves. Chemically, it is an amino acid closely similar in structure to L-glutamine and L-glutamate. L-theanine readily crosses the blood-brain barrier to enact a range of nootropic effects.


The nootropic effects of L-theanine can appropriately be summarized as “relaxed alertness”. In other words, taking L-theanine promotes calmness and tranquility while keeping you mindful and attentive. This makes L-theanine a necessary adjunct to the other ingredients in Best Mood for enhancing both mood and cognitive function. 


Supplementing with L-theanine has been shown to reduce oxidative damage in neurons, and effectively block neurotoxic actions in the brain.8 Further research has shown that consuming L-theanine actively increases alpha waves in the brain, which are known for encouraging relaxation and a heightened sense of well-being. 


Moreover, if you love coffee (like the rest of the world) and thrive on a daily caffeine kick, L-theanine is the best nootropic for you. Research demonstrates that consuming caffeine in conjunction with L-theanine effectively attenuates the side effects of consuming stimulants (e.g. jitters, crashing, inability to concentrate, etc.) while also boosting the nootropic qualities of L-theanine. 


Since Best Mood is a stimulant-free formula, it may be combined with other stimulant-based products. We also went ahead and created a pure L-Theanine + Caffeine product to cater to people who want to take advantage of the synergistic nature of these ingredients. 

References

7. Juneja, L. R., Chu, D. C., Okubo, T., Nagato, Y., & Yokogoshi, H. (1999). L-theanine—a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10(6), 199-204.

9. Song, C. H., Jung, J. H., Oh, J. S., & Kim, K. S. (2003). Effects of theanine on the release of brain alpha wave in adult males. Korean Journal of Nutrition, 36(9), 918-923. 

10. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological psychology, 77(2), 113-122. 

Vitamin B Complex

B vitamins have a vast range of biochemical actions throughout the human body and play a role in nearly every cellular metabolic reaction. B vitamins are essential for energy production, carbohydrate metabolism, cellular respiration, DNA synthesis, neurotransmission, cognitive function, hormonal regulation, and just about any other physiological process you can think of. 


Longitudinal data indicates that having a deficiency in B vitamins (particularly B12 and folate) can rapidly accelerate neurodegenerative processes and increase the risk of cognitive dysfunction. In fact, recent clinical research demonstrated that supplementing with a B vitamin complex (including vitamin B12 and folic acid) was efficacious for cognitive enhancement and blocking neurodegenerative processes. 


Since many people skimp on their fruit and vegetable consumption, supplementing with Best Mood is a practical and smart way to maintain healthy B vitamin intake (remember though, eating a micronutrient-rich diet is always a good idea).  

References

11. Calvaresi, E., & Bryan, J. (2001). B Vitamins, Cognition, and Aging a Review. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 56(6), P327-P339.

12. Van Uffelen, J. G., Chinapaw, M. J., van Mechelen, W., & Hopman-Rock, M. (2008). Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomized controlled trial. British journal of sports medicine.

13. Eussen, S. J., de Groot, L. C., Joosten, L. W., Bloo, R. J., Clarke, R., Ueland, P. M., ... & van Staveren, W. A. (2006). Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. The American journal of clinical nutrition, 84(2), 361-370.

Magnesium 100 mg

Magnesium is one of the most abundant essential minerals in the human body and a key cofactor for more than 300 biochemical processes. Among a myriad of properties in humans, magnesium is necessary for healthy muscular contraction, digestion, immune function, neurotransmitter synthesis, neurotransmission, and bone mineralization.14 


While magnesium is generally present in green vegetables and various beans/lentils, current literature suggests that it is the most common mineral for the population to be deficient in due to continual decreases of natural magnesium content in plant foods (likely arising from modern cultivation processes).15 


Recent neuropharmacological research has shown that hypomagnesemia (magnesium deficiency) is strongly correlated with feelings of anxiety and even panic attacks.16 Preliminary evidence suggests that low magnesium status dysregulates the hypothalamic-pituitary-adrenal (HPA) axis - the primary glands responsible for producing stress hormones (i.e. catecholamines).

Clinical researchers postulate that restoring magnesium levels to the normal range promotes healthy cortisol rhythms, thereby alleviating feelings of anxiety and enhancing mood.17 Magnesium is also necessary for your body to properly absorb and utilize both calcium and vitamin D3, both which are integral to a multitude of physiological processes and overall well-being.     


Best Mood contains one of the most bioavailable forms of magnesium - magnesium glycinate chelate. Be wary of supplements that include magnesium oxide, which has less than 3% bioavailability and is rather useless in humans. 

References

14. Maathuis, F. J. (2009). Physiological functions of mineral macronutrients. Current opinion in plant biology, 12(3), 250-258. 

15. Guo, W., Nazim, H., Liang, Z., & Yang, D. (2016). Magnesium deficiency in plants: an urgent problem. The Crop Journal, 4(2), 83-91. 

16. Sartori, S. B., Whittle, N., Hetzenauer, A., & Singewald, N. (2012). Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology, 62(1), 304-312. 

17. Bandelow, B., Wedekind, D., Pauls, J., Broocks, A., Hajak, G. ½., & Rï¿ ½, E. (2000). Salivary cortisol in panic attacks. American Journal of Psychiatry, 157(3), 454-456.

Astragin 25 mg

AstraGin™ is a patented, high-potency extract of Panax notoginseng and Astragalus membranaceus that significantly increases the bioavailability and absorption of other nutrients. 


We included a clinical dose of AstraGin™ along with the other ingredients in Best Mood in order to effectively maximize the synergy and potency of the formula.